Early development drug formulation on a chip: fabrication of nanoparticles using a microfluidic spray dryer.

Title Early development drug formulation on a chip: Fabrication of nanoparticles using a microfluidic spray dryer

Fabrication of hydrophobic drug nanoparticles using a microfluidic spray dryer

We present a technique for fabricating hydrophobic drug nanoparticles using a microfluidic spray dryer. The nanoparticles are formed by evaporative precipitation of the spray in air at room temperature. Using danazol as a model drug, amorphous nanoparticles are yielded with narrow size distribution, 20-60 nm in diameter. As the device geometry allows us to inject two separate solvent streams, t...

Steroid Nanocrystals Prepared Using the Nano Spray Dryer B-90

The Nano Spray Dryer B-90 offers a new, simple, and alternative approach for the production of drug nanocrystals. In this study, the preparation of steroid nanocrystals using the Nano Spray Dryer B-90 was demonstrated. The particle size was controlled by selecting the mesh aperture size. Submicrometer steroid particles in powder form were successfully obtained. These nanoparticles were confirme...

Drug Discovery Acceleration Using Digital Microfluidic Biochip Architecture and Computer-aided-design Flow

A Digital Microfluidic Biochip (DMFB) offers a promising platform for medical diagnostics, DNA sequencing, Polymerase Chain Reaction (PCR), and drug discovery and development. Conventional Drug discovery procedures require timely and costly manned experiments with a high degree of human errors with no guarantee of success. On the other hand, DMFB can be a great solution for miniaturization, int...

Fabrication and in vitro evaluation of Ketotifen Fumarate-loaded PLGA nanoparticles as a sustained delivery system

Abstract Ketotifen fumarate is a non-bronchodilator anti-asthmatic drug which inhibits the effects of certain endogenous substances known to be inflammatory mediators, and thereby exerts antiallergic activity. The present study describes the formulation of a sustained release nanoparticle (NP) drug delivery system containing ketotifen, using poly (D,L lactide-co-glycolide acid) (PLGA). Biodegra...